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Ganga river is a lifeline northern part of India. Kanpur city, a industrial hub is also situated on the bank of river Ganga. Huge amount of treated or partially treated waste water reaches to Ganga and influence the water quality. Therefore study of physico-chemical property of Ganga river at Kanpur was undertaken. 5 sampling stations were selected for river water analysis. In this study various physico-chemical parameters like pH, turbidity, EC, TDS, TSS, alkalinity, total hardness, calcium, magnesium, chloride, dissolved oxygen, biochemical oxygen demand, chemical oxygen demand, sulphate, phosphate, nitrate, total coliform and fecal coliform were analyzed. The obtained results were compared with prescribed standard. Water Quality Index (WQI) was also calculated to find out the overall water quality of river in the study area. Observed results shows that the water quality of all sampling stations was above 100-point scale which means that all the sampling stations were unsuitable for drinking purpose.